WebOct 28, 2024 · (A) CircRNAs can serve as miRNA sponges by competitively binding to miRNA (s) via base-pairing interactions, causing stabilization of target transcript (s) of the sequestered miRNA (s), and thus making it more available for translation. (B) CircRNAs can sponges protein by binding to them and thus indirectly regulating their functions. WebApr 6, 2024 · Request PDF On Apr 6, 2024, Sima Orouei and others published Circular RNAs (CircRNAs) in cancer therapy response: Biological aspects Find, read and cite all the research you need on ResearchGate
Delivering the next generation of cancer …
WebCircular RNAs (circRNAs) are a type of endogenous non-coding RNA and a critical epigenetic regulation way that have a closed-loop structure and are highly stable, conserved, and tissue-specific, and they play an important role in the development of many diseases, including tumors, neurological diseases, and cardiovascular diseases. … WebMay 19, 2024 · circMET is an onco-circRNA that induces HCC development and immune tolerance via the Snail/DPP4/CXCL10 axis. Furthermore, sitagliptin may enhance the efficacy of anti-PD1 therapy in a subgroup of patients with HCC. Introduction Hepatocellular carcinoma (HCC) is the most frequent hepatic malignancy and has a poor prognosis [ 1 ]. dgft prohibited items
Mechanisms Regulating Abnormal Circular RNA …
WebMar 11, 2024 · Circular RNAs (circRNAs), belonging to the non-coding RNAs (ncRNAs), are connected end to end to form covalently closed single-chain circular molecules. … WebJul 15, 2024 · Circular RNAs (circRNAs) are circular RNA molecules without a 5′ cap and a 3′ poly (A) tail structure, which play an important role in tumor development, invasion and metastasis, etc. However, the mechanism of circRNA dysregulation in … WebAug 1, 2024 · Circular RNAs as therapeutic targets in cancer Both oncogenic and tumor suppressive circRNAs can potentially serve as therapeutic targets in cancer. The back splicing junction sequence is unique to specific circRNAs and allows specific targeting of specific circRNAs without affecting the parental mRNA. cibc machine locations