Ctcf boris

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August undefined, 2024

WebJun 23, 2024 · Summary. CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer states. Unexpectedly, BORIS-null mice have only minimal germ cell defects. To understand the CTCF-BORIS relationship, mouse models with varied CTCF and BORIS … WebThe CTCF-only enrichment is characteristic for evolutionary old and inactive repeat classes, while BORIS and CTCF co-binding predominately occurs at uncharacterized tandem repeats.

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WebOct 1, 2024 · Indeed, BORIS is one of the most commonly activated CG genes in cancer ( 11) and has been proposed as an activator of other CG genes ( 12 ), making it an attractive immunotherapy target ( 13 ). BORIS is the sole paralog of CTCF (CCCTC-binding factor) gene which encodes a multifunctional DNA-binding protein ( 14 ). WebPreviously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. To develop an understanding of the functional activities of BORIS, we generated BORIS knockout (KO) mice. howler fungicide mode of action

The cancer-associated CTCFL/BORIS protein targets multiple …

WebApr 27, 2024 · As a consequence, CTCF and BORIS proteins bind to virtually the same DNA motifs in vivo and in vitro29-33, however, they differ dramatically in their N- and C-terminal domains34. Recent studies show that CTCF and BORIS interact with different protein partners35-37. Notably, the divergence of the N-terminal region of the two … WebJun 19, 2012 · CTCF is a ubiquitous epigenetic regulator that has been proposed as a master keeper of chromatin organisation. CTCF-like, or BORIS, is thought to antagonise CTCF and has been found in normal testis, ovary and a large variety of tumour cells. The cellular function of BORIS remains intriguing although it might be involved in … WebFeb 1, 2014 · CTCF is the paralogue of BORIS and is involved in the organization of chromatin, regulation of cellular proliferation and apoptosis, genomic imprinting and X … howler football

The combined action of CTCF and its testis-specific paralog …

Ctcf boris

A Cell Cycle Role for the Epigenetic Factor CTCF-L/BORIS

WebMay 14, 2002 · The ubiquitous, highly conserved, multivalent 11-zinc-finger (ZF) factor CTCF plays multiple roles in gene regulation, depending on the combinatorial utilization of different ZFs to bind varying CTCF target sites ().CTCF–DNA complex formation can be regulated by CpG-specific DNA methylation (2, 3) if the involved CpG nucleotides are … WebCTCF and BORIS can be deregulated in cancer. The tumour suppressor gene CTCF can be mutated or deleted in cancer, or CTCF DNA binding can be altered by epigenetic …

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WebJan 15, 2008 · BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as ... WebAug 29, 2008 · CTCF and BORIS have opposite regulatory effects on human cancer-testis genes, the anti-apoptotic BAG1 gene, the insulin-like growth factor 2/H19 imprint control …

WebJan 1, 2024 · CCCTC-binding factor (CTCF) is a conserved, essential regulator of chromatin architecture containing a unique array of 11 zinc fingers (ZFs). Gene duplication and … WebBORIS (CTCFL) is a paralogous gene that carries the same DNA binding domain as CTCF but is normally expressed only during spermatogenesis. In cancer, CTCF appears to function as a tumor suppressor gene whereas BORIS becomes aberrantly expressed in many cancers – thus is classed as a cancer-testis gene and is a possible target for …

WebNov 20, 2024 · Abstract. The cancer-testis antigen CTCFL/BORIS (Brother of Regulator of Imprinted Sites) also known, as a paralog of CTCF -the "master weaver of the genome" … WebJan 14, 2024 · BORIS (CTCFL), a germline-specific paralog of CTCF, was unable to anchor cohesin to CTCF DNA binding sites. Furthermore, CTCF–BORIS chimeric constructs …

WebThis antibody is not cross-reactive with BORIS. Background/Target Information This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences ...

WebAug 14, 2015 · CTCF and BORIS encode proteins that share an almost identical DNA binding domain recognizing the same DNA sequences in vivo and in vitro [ 29 – 32 ]. It … howler games hq youtubeWebDec 14, 2011 · BORIS, or CTCFL, the so called Brother of the Regulator of Imprinted Sites because of the extensive homology in the central DNA binding region of the protein to the related regulator, CTCF, is expressed in early gametogenesis and in multiple cancers but not in differentiated somatic cells. Thus it is a member of the cancer testes antigen group … howler groupWebJun 18, 2012 · CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigenetic events. The function of CTCFL or BORIS, the testis-specific paralog of CTCF, is less clear. Using immunohistochemistry on testis … howler gaucho shirt howler h20WebMay 23, 2024 · Intriguingly, motifs specific to key TFs in islets, including BORIS, BACH2, FOXO1, FOXA2, NEUROD1, MAFA and PDX1 as well as the motif for CTCF were significantly enriched in the ATAC-seq peaks ... howler githubWebNov 26, 2013 · BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. howler harryWebPrimePCR™ Template for Probe Assay: CTCF, Human Reaction: 200 x 20 µl reactions Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay. List Price: $215.00 Your Price: Log In Quantity: Add to Cart [ Add to My PrimePCR ] ... howler hacienda