Cytohubba stress

Author: tbww

August undefined, 2024

WebMar 15, 2024 · CytoHubba, which has been widely used to explore important nodes in biological networks, was then applied to identify the lip and oral cavity carcinoma hub proteins in the PPI network. ... The PI3K/Akt pathway is a central controller of viability in response to cell stress (e.g., pH, nutrient, and oxygen levels), and deregulation of the … WebNov 25, 2024 · It can play a protective role on nerve cells through anti-inflammatory response, antioxidant stress and inhibition of apoptosis. In addition, it also has estrogen like effect on nerve cells. In...

Identification of Potential Key Genes and Molecular ... - Hindawi

WebApr 1, 2024 · The extent of drought stress is varieties and time-dependent, however, the molecular response mechanisms of drought tolerance in sunflower with different varieties are still unclear. ... CytoHubba analysis showed that the top 10 genes all encoded ribosomal proteins. Up-regulated genes were enriched in the KEGG pathway of … WebJan 4, 2024 · We identified 17 hub genes that were closely associated with oxidative stress in AS and constructed a four-gene (aldehyde dehydrogenase six family member A1 ( ALDH6A1 ), eukaryotic elongation factor 2 kinase ( EEF2K ), glutaredoxin ( GLRX) and l -lactate dehydrogenase B ( LDHB )) diagnostic model with good accuracy. fish and wildlife washington phone number

cytoHubba: Identifying hub objects and sub-networks from …

Web 目的运用生物信息学分析，探讨硫利达嗪抗宫颈癌的潜在作用机制。方法通过PharmMapper工具预测能够与硫利达嗪相互作用的靶基因，然后使用STRING在线工具对靶基因进行通路和组织表达富集分析。使用GeneCards和DisGeNET数据库筛选宫颈癌相关基因，与硫利达嗪的靶基因取交集，得到硫利 ... WebDec 7, 2024 · STRING, Cytoscape, MCODE and Cytohubba were used to construct a protein-protein interaction (PPI) network and screen key EP-DEGs. Key EP-DEGs levels … WebJul 30, 2024 · Stress is a state of the body a non-specific response to any demand for change. Cancer had a deep relation with stress. Activation of the stress response and … can a 11 year old date a 17 year old

Frontiers Identification of Hub Genes and Their …

Computational identification of biomarker genes for lung …

WebApr 11, 2024 · In addition, the MCC module in the Cytohubba plugin filtered the top 20 hub genes in each of the three datasets and then took the intersection of the top 20 hub genes to determine the common hub genes by Venn software, ... (ASK1) by histone modifications in sufficient cells induces oxidative stress to reduce glomerular injury. Bioinformatics ... WebDec 3, 2024 · The gene network was analyzed using 12 scoring methods available in Cytohubba - betweenness, bottleneck, closeness, clustering coefficient (CC), degree, density of maximum neighborhood component (DMNC), eccentricity (EcC), edge percolated component (EPC), maximal clique centrality (MCC), maximum neighborhood component … fish and wineWebCytoHubba provides 11 topological analysis methods including Degree, Edge Percolated Component, Maximum Neighborhood Component, Density of Maximum Neighborhood … fish and wildlife wetland map

"WebOct 3, 2024 · The results demonstrate that baicalin may exert anti-oxidative stress effects by targeting NOX4, providing new mechanisms and insights to baicalin for the treatment … " - Cytohubba stress

Cytohubba stress

Frontiers Periostin Contributes to Immunoglobulin a Nephropathy …

WebJan 1, 2024 · Using Cytohubba centrality analysis, Genes and their regulators were subjected to five different statistical methods (Maximal Clique Centrality (MCC), Maximum Neighborhood Component (MNC), Stress, Density of Maximum Neighborhood Component (DMNC), and Degree) to identify their connectivity (Chin et al., 2014). DE-centrality hub … WebThe plug-in CytoHubba (version 1.6) in Cytoscape was used to explore significant genes in the PPI network, and the genes with most interactions were referred as hub genes, which might play core roles in the disease pathogenesis. 17 We used Maximal Clique Centrality (MCC) to calculate the hub genes. Results Identification of DEGs

Did you know?

WebIn the comparisons, 932 and 384 overlapping transcripts were consistently up- and down-regulated, respectively. Combining the results of protein-protein interaction network analysis MCODE and CytoHubba, 55 up-regulated hub genes from four clusters and 9 down-regulated genes were identified. WebMar 4, 2024 · A plugin named cytoHubba was introduced to screen hub genes of PPI network in Cytoscape. CytoHubba can provide 12 topological analysis methods including Betweenness, BottleNeck, Closeness, Clustering Coefficient, Degree, DMNC, EcCentricity, EPC, MCC, MNC, Radiality and Stress based on shortest paths . Results. Normalization …

WebJul 30, 2024 · Stress is a state of the body a non-specific response to any demand for change. Cancer had a deep relation with stress. Activation of the stress response and exposure to the associated hormones could promote the growth and spread of tumors. The immune system can be important for finding and eliminating cancer cells.

WebThe CYBA gene provides instructions for making a protein called the cytochrome b-245 alpha chain (also known as p22-phox). This protein is one part (subunit) of a group of … WebAug 8, 2024 · Twelve methods in cytoHubba (Betweenness, BottleNeck, Closeness, Clustering Coefficient, Degree, DMNC, EcCentricity, EPC, MCC, MNC, Radiality, and Stress) were used to rank and evaluate the hub genes, and to finally generate the hub gene network; DAVID was used for hub gene enrichment analysis of GO, and KEGG further …

WebFinally, the hub genes were screened from the PPI network using the MCC algorithm of CytoHubba plugin. ... Functional enrichment analysis indicated that DEGs were mainly …

WebJan 7, 2024 · Figure 3.Screen of upregulated overlapping DEGs for key genes. (A,B) Top 15 upregulated overlapping DEGs analyzed with the stress (A) and betweenness (B) algorithms of cytoHubba plugin in Cytoscape, shown in yellow, orange, and red in the middle of the circle. Different colors represent different connectivity with other genes in … can a 11 year old get snapchatWebMar 17, 2024 · Combining multiple ML and cytohubba algorithms yielded 11 relevant genes. ... (Figure 5), in order to further screen for key hub genes, the Stress, MCC, Degree, EPC, EcCentricity, Radiality, Closeness and Betweenness algorithms were used to calculate the associated gene scores (Supplementary Figure S2A–G). can a 11 year old girl date a 12 year old boyWebFeb 22, 2024 · We used algorithms of Cytohubba, molecular complex detection, Lasso logistic regression, and support vector machine to identify the key biomarkers. ... Cardiac myocytes have elevated levels of THBS1 in response to stress stimulation 15 and THBS1 can release active TGF-β and trigger fibrosis. 16 This trial demonstrates that THBS1 is … can a 11 year old become pregnantWebMar 14, 2024 · Stress cardiomyopathy (SCM) is a transient reversible left ventricular dysfunction that more often occurs in women. ... CRP, ALB, APOE, APOB, MFGE8, GAPDH, and PLAT, finally utilizing the cytoHubba plug-in to determine APOE, MFGE8, ALB, APOB, SAA1, A2M, and C3 as the hub gene, as shown in Figure 8 and Table 4. … can a 11 year old have a bank accountWebExplore important nodes/hubs and fragile motifs in an interactome network by several topological algorithms including Degree, Edge Percolated Component (EPC), Maximum … can a 11 year old get a job ukWebfrom publication: cytoHubba: Identifying hub objects and sub-networks from complex interactome Background Network is a useful way for presenting many types of biological data including protein ... can a 11 year old join a gymWebNov 26, 2024 · The key genes were output by the four algorithms' maximum neighborhood component (MNC), degree, maximal clique centrality (MCC), and stress in cytoHubba … can a 11 year old have instagram