WebJul 20, 2024 · BackgroundChronic myeloid leukemia (CML) is an acquired hematopoietic stem malignant disease originating from the myeloid system. Long non-coding RNAs (lncRNAs) have been widely explored in cancer tumorigenesis. However, their roles in CML remain largely unclear.MethodsThe peripheral blood mononuclear cells (PBMCs) and … WebApr 17, 2024 · The complex enhances the penultimate step in glycolysis, which sustains high proliferation and drives tumourigenesis independent of nuclear paraspeckles. Cytoplasmic NEAT1_1 has also been described as a regulator of stem cell self-renewal in acute myeloid leukaemia (AML) . In contrast to its role in breast cancer, however, …
促癌基因NEAT1抑制白血病 - 分析行业新闻
WebMechanistically, NEAT1_1 is released from the nucleus into the cytoplasm of AML cells, regulated by transcription factor C/EBPβ and nuclear protein NAP1L1. Cytoplasmic NEAT1_1 interacts with Wnt component DVL2 and E3 ubiquitin ligase Trim56, facilitates Trim56‐mediated DVL2 degradation, and thus suppresses Wnt signaling. Collectively, … WebJan 26, 2024 · NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling As an essential component of paraspeckles, nuclear paraspeckle assembly transcript 1 (NEAT1) localizes in the nucleus, promoting progression of various malignant solid tumors. ray\u0027s furniture elizabethtown nc
LncRNA NEAT1 regulates HCV-induced Hepatocellular carcinoma …
WebOct 13, 2024 · It is demonstrated that NEAT1_1 suppresses leukemogenesis and LSC function but is dispensable for normal hematopoiesis. Mechanistically, NEAT1_1 is … WebOct 14, 2024 · 进一步研究发现，细胞质中的neat1_1通过调控wnt信号通路，抑制aml干细胞的自我更新、促进细胞分化。 研究分析tcga和geo数据库发现，neat1在aml细胞中的表 … WebMar 23, 2024 · Cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous disease with different prognoses. Researches on prognostic biomarkers … ray\\u0027s furniture rosenberg tx