Cytoplasmic retention
WebRetention of the Unspliced RNAs and Transcriptional Down-Regulation of the Splicing-Defective Genes Andrea B. Eberle, Viktoria Hessle, Roger Helbig, Widad Dantoft, Niclas Gimber, Neus Visa* ... site of translation in the cytoplasm. The transcripts are associated with different types of RNA-binding proteins throughout the gene expression pathway ... WebJun 25, 2024 · First, ZO-2 undergoes translocation from the nucleus to the cytoplasm, which facilitates the nuclear exit of YAP and/or the retention of YAP in the cytoplasm. …
Cytoplasmic retention
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WebThe cytoplasmic retention of TFE3 by mTOR in preadipocytes is sensitive to amino acids but not to the presence of growth factor-rich FBS dialyzed to remove amino acids (dFBS) (Fig. 4A). In the absence of FLCN, TFE3 is nuclear even in the presence of amino acids ( Fig. 4 A), consistent with the reported role of FLCN as a transducer of amino acid ... WebThe cytoplasmic retention of the precursor molecule is controlled by a small region in its C-terminal part. We show that this region is responsible for the observed lack of …
WebFeb 1, 2003 · The interphase cytoplasmic location of cyclin B1/Cdc2 reflects continuous, albeit slow, nuclear import and much more rapid nuclear export. In contrast, the sudden nuclear accumulation of the complex before entry into mitosis reflects a marked increase in the import rate, with a concomitant inhibition of cyclin B1 nuclear export. WebThe cytoplasmic retention of the precursor molecule is controlled by a small region in its C-terminal part. We show that this region is responsible for the observed lack of DNA binding of the p50 precursor and controls the extent of …
WebJun 6, 2014 · The results introduce a new paradigm where cytokine treatment prolongs nuclear retention simultaneous with decreasing rather than increasing the rate of nuclear import. ... It would thus appear that the C-terminal tail of STAT3α contributes to cytoplasmic retention of STAT3 in the cytoplasm under basal conditions, with S727 within it helping ... WebOct 17, 2024 · This new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote the evolution of complexity in eukaryotes by shaping the genomic content through constructive neutral evolution.
WebOct 17, 2024 · Cytoplasmic fusion is not followed by karyogamy, resulting in a dikaryotic cell. After cell fusion on the plant surface, the G2 cell cycle arrest is sustained, and the single dikaryotic cell grows in a polar …
WebJun 20, 2000 · Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid … highland lawn mower service highlandWebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic … how is hail measuredWebMicrotubules Emanate from the Centrosome in Animal Cells. In most animal cells, there is a single, well-defined MTOC called the centrosome, located near the nucleus.From this … how is hair analysis used in forensic scienceWebFeb 15, 2024 · Our findings suggest that SET SUMOylation stimulates its cytoplasmic retention and inhibits PP2A activity, consequently leading to tau hyperphosphorylation and cognitive impairments, which provides a new insight into the AD-like tau pathology. Keywords: Alzheimer’s disease; Cognitive impairments; PP2A; SET SUMOylation; Tau … highland lawn mower highland indianaWebDec 7, 2024 · Due to its potent cytoplasmic retention activity, we named this region (352–357 aa) Cytoplasmic Anchoring Signal, CAS. T o further elucidate the working … how is hair chalk madeWebJun 26, 2024 · Abstract. The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and organs during development and in disease. When the Hippo … highland law office jackson tnWebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote the evolution of complexity in eukaryotes by shaping the genomic content through constructive neutral evolution. Introduction how is hair and fibre evidence stored