Highlights in pathogenesis of vitiligo
WebApr 26, 2024 · Abstract Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes and results in patches of depigmentation that are visible as white spots. Recent research studies have yielded a strong … WebNov 16, 2024 · Vitiligo is a relatively common acquired disorder of pigmentation characterized by the development of well-defined, depigmented macules on the skin. Biopsies of lesional skin reveal a loss of epidermal melanocytes [ 1-4 ]. Lesions may occur in a localized or generalized distribution and may coalesce into large, depigmented areas.
Highlights in pathogenesis of vitiligo
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WebMar 21, 2024 · Vitiligo is the most common acquired pigmentary disorder, which afflicts 0.5%–1% of the world population, and is characterized by depigmented skin patches resulting from melanocyte loss. Vitiligo has a complex etiology and varies in its manifestations, progression, and response to treatment. WebJan 1, 2008 · The pathogenesis of vitiligo was examined for clues to the pigmentary changes that may occur after treatment with topical imiquimod. The literature varies on the pigmentary changes induced by topical use of imiquimod. The US Food and Drugs Administration lists 68 reports of pigmentary changes out of a total of 1257 reports …
WebNov 10, 2024 · Vitiligo occurs when pigment-producing cells (melanocytes) die or stop producing melanin — the pigment that gives your skin, hair and eyes color. The involved patches of skin become lighter or white. It's … WebFeb 16, 2024 · Pathophysiology. Vitiligo is commonly known as multifactorial polygenic disorder and has complex pathogenesis. It is commonly associated with both non-genetic and genetic factors. However various theories have been proposed about its pathogenesis but the exact etiology is still unknown. The generally agreed principles are the absence of ...
WebThe critical role of miRNAs in skin-specific autoimmune diseases that proved to be potential biomarkers for autoimmune skin disorders, warranting their exploration as therapeutic targets, is highlighted. BACKGROUND Psoriasis and vitiligo are both chronic, skin-specific diseases classified as autoimmune diseases due to the involvement of several … WebJan 6, 2024 · Collectively, the current evidence nominates GzmB as a promising biomarker and therapeutic target in autoimmune skin disease. Figure 1. Current understanding of GzmB in cutaneous autoimmune diseases, including psoriasis, vitiligo, systemic sclerosis, alopecia areata, interface dermatitis, and bullous pemphigoid. Not to scale.
WebMar 2, 2024 · Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant progress has been made in understanding vitiligo pathogenesis over the past 30 years, but only through perseverance, collaboration, and open-minded discussion.
WebMar 1, 2015 · Many theories were elaborated to clarify vitiligo pathogenesis. It is a multifactorial disease involving the interplay of several factors. Future research is needed … in cold blood miniseries castWebMay 25, 2024 · Combined, these associations highlight the key players in the contribution of T-cells to the pathogenesis of vitiligo. Other candidate loci for vitiligo in several ethnicities include FASLG , a member of the TNF superfamily, and GZMB, a protease, both of which point to a role of dysregulated apoptosis in vitiligo. in cold blood kansasWebVitiligo is an acquired chronic disease of depigmented white macules and patches that result from destruction of melanocytes in the affected skin. Vitiligo is common and … in cold blood nature vs nurtureWebSep 16, 2024 · Abstract and Figures Vitiligo is an autoimmune skin disease characterized by presence of pale patchy areas of depigmentation. MicroRNAs (miRNAs) are important regulators of gene expression and... easycover insurance canadaWebSep 3, 2024 · Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant progress has been made in understanding vitiligo pathogenesis over the past 30 years, but only through ... easyflow 9000 fineWebDec 5, 2024 · As discussed above, IFN-γ signaling pathway appears as a key driver of vitiligo pathogenesis, including some non-immunological processes. IFN-γ is produced by … in cold blood nature vs nurture quotesWebJun 4, 2015 · A vitiligo-like leukoderma may occur in patients with metastatic melanoma. Vitiligo can also be induced by drugs, such as immune checkpoint inhibitors … easygamer89